Colonization and Associated Risk Factors of Methicillin-Resistant <i>Staphylococcus aureus </i>Among People Living with HIV at Jimma Medical Center, Southwest Ethiopia

Nasal colonization of Methicillin-resistant Staphylococcus aureus (MRSA) is a potential source spread and prerequisite for staphylococcal infections. MRSA colonization, which causes infection in people living with HIV (PLWHIV), could lead to longer hospital stay, increased medical costs, prolonged antibiotic administration. This study aims determine the nasal rate, associated risk factors, susceptibility patterns among PLWHIV at Jimma University Medical Center (JUMC), Southwest Ethiopia. An institution-based cross-sectional was conducted JUMC from July October 2021. Data on factors were collected by using structured questionnaire reviewing patients’ records. swabs cultured mannitol salt agar S. identified standard bacteriological procedures. isolates subjected tests modified Kirby- Bauer disc diffusion method resistance cefoxitin (30µg) disk signified MRSA. Binary multivariable logistic regressions employed identify p-value < 0.05 taken as statistically significant. A total 351 included our study. The overall rate 17.7% (62/351) 6.0% (21/351) Hospitalization previous six months, 27.35 (95% CI: 4.042-185.08; p = 0.001), viral load greater than 1000 copies/mL, 24.44 1.885-317.12; p = 0.014) rural residence, 9.49 1.404-64.19; 0.021), odds colonization. Among isolates, 81.2% multidrug resistant highest against Erythromycin (85.8%), followed Sulfamethoxazole-trimethoprim (66.6%), Clindamycin (66.6%). Only 23.7% Chloramphenicol Gentamicin. relatively low documented PLWHIV. majority were, however, multidrug-resistant, calls regular screening during their follow-up periods control prevention